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  1. Khrustalev V.V., Barkovsky E.V. Bioinformatical approaches for studies on replication-associated and transcription-associated mutational pressure, interpretations and applications // Advances in Genetics Research (Nova Science Publishers, Inc., New York) - 2011. - Vol.6. - P.1-108.


 

SciTopics

 

  1. Khrustalev V.V., Barkovsky E.V. Original computer algorithms for studies on directional mutational pressure // SciTopics 2011.

  2. Khrustalev V.V., Barkovsky E.V. Numerous consequences of the directional mutational pressure // SciTopics 2010.


 

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  1. Khrustalev V.V., Lelevich S.V., Barkovsky E.V. Zebra Finch glucokinase containing two homologous halves is an in silico chimera // ISRN Computational Biology. 2013. Vol.2013. N. 790240. P. 1 6.

  2. Lelevich S. V., Khrustalev V.V., Barkovsky E.V. Inhibition of rat muscle and liver phosphofructokinases by high doses of ethanol // Biochemistry Research International. 2013. Vol.2013. N. 495135. P. 1 8.

  3. Lelevich S.V., Khrustalev V.V., Barkovsky E.V., Shedogubova T.A. The influence of ethanol on pyruvate kinases activity in vivo, in vitro, in silico // American Journal of Medical and Biological Research. 2013. Vol.1. No.1. P. 6-15.

  4. Khrustalev V.V., Barkovsky E.V. In silico directed mutagenesis using software for glycosylation sites prediction as a new step in antigen design // Journal of Integrated OMICS. 2012. Vol.2. Issue 1. P.31-36.

  5. Khrustalev V.V., Barkovsky E.V., Vasilevskaya A.E., Skripko S.M., Kolodkina V.L., Ignatyev G.M., Semizon P.A. A method for estimation of immunogenic determinants mutability: case studies of HIV1 gp120 and diphtheria toxin // Journal of Integrated OMICS. 2011. Vol.1. Issue 2. P.236-252.

  6. Khrustalev V.V. HIV1 V3 loop hypermutability is enhanced by the guanine usage bias in the part of env gene coding for it // In Silico Biology. 2009. Vol.9. Number 4. P.255-269. (Electronic version: Vol.9. 0022).

  7.  Khrustalev V.V., Barkovsky E.V. Main Pathways of Proteome Simplification in Alphaherpesviruses Under the Influence of the Strong Mutational GC-pressure // Journal of Proteomics and Bioinformatics 2009. Vol. 2. Issue 2. P.88-96.

 


 

 

  1. Khrustalev V.V., Khrustaleva T.A., Barkovsky E.V. Random coil structures in bacterial proteins. Relationships of their amino acid compositions to flanking structures and corresponding genic base compositions // Biochimie 2013. Vol.95. Issue 9. P. 1745-1754.

  2. Khrustalev V.V., Ghaznavi-Rad E., Neela V., Shamsudin M., Amouzandeh-Nobaveh A., Barkovsky E.V. Short repeats in the spa gene of Staphylococcus aureus are prone to nonsense mutations: stop codons can be found in strains isolated from patients with generalized infection // Research in Microbiology 2013. Vol.164. Issue 9. P. 913922.

  3. Khrustalev V.V., Barkovsky E.V. Stabilization of secondary structure elements by specific combinations of hydrophilic and hydrophobic amino acid residues is more important for proteins encoded by GC-poor genes  // Biochimie - 2012. - Vol.94. - P. 2706-2715.

  4. Khrustalev V.V., Arjomanzadegan M., Barkovsky E.V., Titov L.P. Low rates of synonymous mutations in sequences of Mycobacterium tuberculosis GyrA and KatG genes  // Tuberculosis - 2012. - Vol.92. - Issue 4. - P. 333-344.

  5. Khrustalev V.V., Barkovsky E.V. A blueprint for a mutationist theory of replicative strand asymmetries formation  // Current Genomics - 2012. - Vol.13. - Issue 1. - P. 55-64.

  6. Khrustalev V.V., Barkovsky E.V. Percent of highly immunogenic amino acid residues forming B-cell epitopes is higher in homologous proteins encoded by GC-rich genes // Journal of Theoretical Biology 2011. Vol.282. P.71-79.

  7. Khrustalev V.V., Barkovsky E.V. Unusual nucleotide content of Rubella virus genome as a consequence of biased RNA-editing: comparison with Alphaviruses // International Journal of Bioinformatics Research and Applications 2011. Vol.7. Issue 1. P.82-100.

  8. Khrustalev V.V., Barkovsky E.V. Protoisochores in certain archaeal species are formed by replication-associated mutational pressure // Biochimie. 2011. Vol.93. Issue 2. P.160-167.

  9.  Khrustalev V.V., Barkovsky E.V. The level of cytosine is usually much higher than the level of guanine in two-fold degenerated sites from third codon positions of genes from Simplex- and Varicelloviruses with G+C higher than 50% // Journal of Theoretical Biology. 2010. Vol.266. Issue 1. P.88-98.

  10.  Khrustalev V.V., Barkovsky E.V. The probability of nonsense mutation caused by replication-associated mutational pressure is much higher for bacterial genes from lagging than from leading strands // Genomics. 2010. Vol.96. Issue 3. P.173-180.

  11. Khrustalev V.V. Levels of HIV1 gp120 3D B-cell epitopes mutability and variability: searching for possible vaccine epitopes // Immunological Investigations. 2010. Vol.39. Issue 6. P.551-569.

  12. Khrustalev V.V., Barkovsky E.V. Study of completed archaeal genomes and proteomes: hypothesis of strong mutational AT pressure existed in their common predecessor // Genomics, Proteomics and Bioinformatics. 2010. Vol.8. Issue 1. P.22-32.

  13. Khrustalev V.V. Mutational pressure makes HIV1 gp120 linear B-cell epitopes shorter and may lead to their disappearance. // Molecular Immunology. 2010. Vol.47. Issues 7-8. P.1635-1639.

  14. Khrustalev V.V., Barkovsky E.V. Mutational pressure is a cause of inter- and intragenomic differences in GC-content of simplex and varicello viruses // Computational Biology and Chemistry. 2009. Vol.33. Issue 4. P.295-302.

  15. Khrustalev V.V. Can mutational GC-Pressure create new linear B-cell epitopes in Herpes Simplex virus type 1 glycoprotein B? // Immunological Investigations. 2009. Vol.38. Issue 7. P.613-623.

  16.  Barkovsky E.V., Khrustalev V.V. Inverse Correlation between the GC Content of Bacterial Genomes and Their Level of Preterminal Codon Usage // Molecular Genetics, Microbiology and Virology. 2009. Vol.24. No.1. P.17-23.

  17. Khrustalev V.V., Barkovsky E.V. Mutational Pressure in Genomes of Human a-Herpesviruses // Molecular Genetics, Microbiology and Virology. 2008. Vol.23. No.2. P.94-100.

  18. Khrustalev V.V., Barkovsky E.V. An in-silico study of alphaherpesviruses ICP0 genes: Positive selection or strong mutational GC-pressure? // IUBMB Life. 2008. Vol.60. Issue 7. P.456-460.

 


 

 

 

1.      Khrustalev V. V. , Lelevich S. V., Barkovsky E. V. Docking of ethanol to 3D models of human and rat muscle and liver phosphofructokinases // Acta Biochimica Polonica. 2013. Vol. 60. S. 1. P. 137.

2.      Khrustaleva T. A., Khrustalev V. V., Barkovsky E. V. Structural context around amino acid residues binding Mn+2 ions in bacterial proteins // Moscow Conference on Computational Molecular Biology (MCCMB'13): Proceedings. 2013 N. 124.

3.      Lelevich S. V., Khrustalev V. V., Barkovsky  E. V. Deep insights into the history of hexokinases evolution based on mutational pressure theory // Moscow Conference on Computational Molecular Biology (MCCMB'13): Proceedings. 2013 N. 125.

4.      Khrustalev V. V., Vasilevskaya A. E., Skripko S. M., Barkovsky E. V., Semizon P. A. Affinity purification of antibodies cross-reacting with peptide NQ21 corresponding to the less mutable HIV1 gp120 epitope // HIV in European Region Unity and Diversity, Abstract Book, Tallinn, Estonia AIDS 2011 Tallinn, 2011. P. 145.

5.      Khrustalev V. V., Barkovsky  E. V. The influence of directional mutational pressure on different characteristics of proteins from proteomes of Simplex- and Varicelloviruses // Book of Abstracts of the 2nd International Congress on Analytical Proteomics, Ourense, Spain ICAP 2011 Ourense, 2011. P. 84.

6.      Khrustalev V. V., Vasilevskaya A. E., Skripko S. M., Barkovsky E. V. Peptide NQ21 corresponding to the HIV1 gp120 epitope with the most unique dipeptide composition shows cross-reactivity with human sera of HIV1-infected persons // Book of Abstracts of the 2nd International Congress on Analytical Proteomics, Ourense, Spain ICAP 2011 Ourense, 2011. P. 190.

7.      Khrustalev V.V., Barkovsky E.V. APOBEC1 editing of HIV1 RNA often leads to the destruction of linear B-cell epitopes: case study of env gene region coding for gp120 protein // New Biotechnology. 2010. Vol.27. Supplement 1. P.S20.

8.      Arjomanzadegan M., Titov L.P., Barkovsky E.V., Khrustalev V.V. Study of GC content in regulatory gene whiB7 from Belarusian resistant isolates of M. tuberculosis. // The International Journal of Tuberculosis and Lung Disease. 2010. Vol. 14. N.11. S.2 P.338.

9.      Khrustalev V.V., Barkovsky E.V., Zadorozniy D.Y. Genotypic method for checking and predicting acyclovir-resistance on the level of human alphaherpesviruses thymidine kinases // FEBS Journal. 2009. Vol.276. Supplement 1. P.317.

10.  Khrustalev V.V., Barkovsky E.V. Common predecessors effect in archaeal genomes and proteomes // Proceedings of the 4-th International Moscow Conference on Computational Molecular Biology MCCMB09. Moscow, Russia. 2009. P.163-164.

11.  Khrustalev V.V., Barkovsky E.V., Zadorozniy D.Y. Computer algorithms for checking the acyclovir-resistance of herpes simplex viruses on the molecular level of the thymidine kinase // Acta Biochimica Polonica. 2008. Vol.55. Supplement 4. P.67.

12.  Khrustalev V.V., Barkovsky E.V. Levels of CpG and GpC dinucleotides in coding districts of archaeal genomes // Computational Phylogenetics and Molecular Systematics CPMS 2007. Conference proceedings. Moscow: KMK Scientific Press Ltd. 2007. P.354-357.